Calcium from foods and supplements can bind to some of the phosphorus in foods and prevent its absorption [1,17]. : 7719-12-2. Triphosphorus pentanitride is an inorganic compound with the chemical formula P 3 N 5. Articles from Britannica Encyclopedias for elementary and high school students. Updates? Phosphorus. Phosphorus is water insoluble. In adults aged 20 and older, the average daily phosphorus intake from foods is 1,189 mg for women and 1,596 mg for men. Commonly, such metal atoms as magnesium, manganese, strontium, and lead substitute for calcium in the mineral, and silicate, sulfate, vanadate, and similar anions substitute for phosphate ions. Boca Raton, Florida: CRC Press; 2018:235-46. de Fornasari ML, Dos Santos Sens YA. Intake recommendations for phosphorus and other nutrients are provided in the Dietary Reference Intakes (DRIs) developed by the Food and Nutrition Board (FNB) at the National Academies of Sciences, Engineering, and Medicine [12]. Parathyroid glands are small glands located in the neck. Serum phosphorus and mortality in the Third National Health and Nutrition Examination Survey (NHANES III): effect modification by fasting. As kidney function declines, phosphate excretion becomes less efficient and serum phosphate concentration rises. They were poisonous to the workers in manufacture,[85] sensitive to storage conditions, toxic if ingested, and hazardous when accidentally ignited on a rough surface. Collectively the EARs, RDAs, AIs and ULs are referred to as Dietary Reference Intakes (DRIs). In humans, phosphorus makes up about 1 to 1.4% of fat-free mass. Relation of serum phosphorus levels to the incidence of atrial fibrillation (from the Atherosclerosis Risk In Communities [ARIC] study). It is also a potent fire suppression agent marketed under the name PhostrEx . J Ren Nutr 2013;23:265-70.e2. Many proteins and sugars in the body are phosphorylated. An analysis of 20032006 NHANES data illustrates the association between CKD and phosphate levels. Phosphorus, however, remained a chemical curiosity until about a century later when it proved to be a component of bones. However, high phosphate levels do not seem to have the same associations in people with milder CKD [50,51]. All of these are radioactive with relatively short half-lives. The principal combined forms in nature are the phosphate salts. I don't believe there is another name for Phosphorus, but it can be spelled: Phosphorous Actually, phosphorus and phosphorous are different things. [, Ito S, Ishida H, Uenishi K, et al. In: Uribarri J, Calvo MS, eds. [, Calvo MS, Lamberg-Allardt CJ. W. H. Freeman and Company, New York; 2010; p. 379. ATP is also important for phosphorylation, a key regulatory event in cells. Phosphorus deficiency in preterm infants is one of the main causes, along with calcium deficiency, of osteopenia of prematurity (impaired bone mineralization) [34]. Foods providing 20% or more of the DV are considered to be high sources of a nutrient, but foods providing lower percentages of the DV also contribute to a healthful diet. Other Names for P4O10. [94] Phosphorus plays a major role in the structural framework of DNA and RNA. These intakes are twice the RDA for adultsless than daily intakes in many men (especially those who are white or Hispanic) and well below the UL. Dietary interventions for mineral and bone disorder in people with chronic kidney disease. Having a high or low level of phosphorus in your bloodstream can signal a number of health conditions. Active ingredient: Phosphorus Alternate names: Dipotassium phosphate, disodium phosphate, phosphatidylcholine, phosphatidylserine Legal status: Available over the counter Suggested dose: 700 milligrams a day in adults Safety considerations: Contraindicated in people with chronic kidney disease Verywell / JR Bee Uses of Phosphorus Increased phosphorus retention often leads to CKD mineral and bone disorder. [, Chines A, Pacifici R. Antacid and sucralfate-induced hypophosphatemic osteomalacia: a case report and review of the literature. Phosphates are a component of DNA, RNA, ATP, and phospholipids, complex compounds fundamental to cells. Word Of The Day Quiz: Vocabulary As Smooth As A Steppe! In: Erdman JW, Macdonald IA, Zeisel SH, eds. The phosphorus content increases from about 0.5% by mass in infancy to 0.651.1% by mass in adults. Introduction. boron sulfur iodine oxygen uranium. Changing phosphorus content of the U.S. diet: potential for adverse effects on bone. A post hoc analysis of data from 7,269 postmenopausal women, mean age 66 years, with osteoporosis found no association between higher serum phosphate levels and risk of cardiovascular outcomes during 4 years of follow-up [61]. Serum levels of phosphorus, parathyroid hormone, and calcium and risks of death and cardiovascular disease in individuals with chronic kidney disease: a systematic review and meta-analysis. Antacids J Ren Nutr 2017;27:97-105. [, Casais MN, Rosa-Diez G, Perez S, et al. Phosphorus can be very dangerous to the ecosystem Up to 1 mg/m3: (APF = 10) Any supplied-air respirator. Impact of phosphorus-based food additives on bone and mineral metabolism. Other important phosphorus-bearing minerals are wavellite and vivianite. Includes a variety of vegetables; fruits; grains (at least half whole grains); fat-free and low-fat milk, yogurt, and cheese; and oils. These drugs can also aggravate existing phosphate deficiency. The effects of hypophosphatemia can include anorexia, anemia, proximal muscle weakness, skeletal effects (bone pain, rickets, and osteomalacia), increased infection risk, paresthesias, ataxia, and confusion [1]. [15][81], Phosphorus is also an important component in steel production, in the making of phosphor bronze, and in many other related products. In utero physiology: role in nutrient delivery and fetal development for calcium, phosphorus, and vitamin D. Am J Clin Nutr 2007;85:604S-7S. People with severe protein or calorie malnutrition can develop refeeding syndrome, also known as refeeding hypophosphatemia, within 2 to 5 days of starting enteral or parenteral nutrition because of the shift in metabolism from a catabolic to an anabolic state [40,41]. Nutr J 2014;13:114. Copper sulfate may produce kidney and cerebral toxicity as well as intravascular hemolysis."[107]. Prophylactic administration of phosphorus and thiamin in patients at risk of refeeding syndrome can prevent this condition [41]. Mineral homeostasis and effects on bone mineralization in the preterm neonate. [95], Every living cell is encased in a membrane that separates it from its surroundings. Kidney Int 2016;89:176-84. P Phosphorus Element information, facts. ), dairy, nuts, whole grains, quinoa and amaranth, beans, tofu, lentils, and soy. FDA does not require food labels to list phosphorus content unless phosphorus has been added to the food. Most Americans consume more than the recommended amounts of phosphorus. Dietary phosphorus is associated with greater left ventricular mass. The relationship between habitual dietary phosphorus and calcium intake, and bone mineral density in young Japanese women: a cross-sectional study. In: Uribarri J, Calvo MS, eds. [105], Organic compounds of phosphorus form a wide class of materials; many are required for life, but some are extremely toxic. Many different types of foods contain phosphorus, including dairy products, meats and poultry, fish, eggs, nuts, legumes, vegetables, and grains [13,14]. Scientific Opinion on Dietary Reference Values for phosphorus. Pyrotechnic applications of the element include tracers, incendiaries, fireworks, and matches. This product is available in the following dosage forms: A meta-analysis of 9 cohort studies in 199,289 patients aged 5073 years with end-stage renal disease showed, for example, that patients on dialysis with the highest phosphate levels (greater than 5.27.5 mg/dL, depending on the study) had a 39% greater risk of all-cause mortality during 12 to 97.6 months of follow-up than those with normal phosphate levels (defined in the analysis as 3.05.5 mg/dL, depending on the study) [49]. The National Institute for Occupational Safety and Health (NIOSH) has set a Recommended exposure limit (REL) of 0.1mg/m3 over an 8-hour workday. Part 9", "Industrial disease due to certain poisonous fumes or gases", Phosphorus Cycle Terrestrial Phosphorus Cycle, Transport of Phosphorus, "Enzymatic Synthesis of Acetyl Phosphate", "Refeeding syndrome: what it is, and how to prevent and treat it", "Calcium, Phosphorus and Human Bone Development", "Overview on Dietary Reference Values for the EU population as derived by the EFSA Panel on Dietetic Products, Nutrition and Allergies", "Federal Register May 27, 2016 Food Labeling: Revision of the Nutrition and Supplement Facts Labels. High phosphorus intakes might be signs of diets that are unhealthy in other ways, for example [63]. [, Palmer SC, Hayen A, Macaskill P, et al. The two main forms of phosphorus are white phosphorus and red phosphorus. Symptoms of hypophosphatemia include neurological dysfunction and disruption of muscle and blood cells due to lack of ATP. Am J Kidney Dis 2017;69:200-9. Join the ODS Email List. JJ Am Soc Nephrol 2014;25:2730-9. 1314-80-3 - CYQAYERJWZKYML-UHFFFAOYSA-N - Phosphorus sulfide - Similar structures search, synonyms, formulas, resource links, and other chemical information. Karpen HE. Serum phosphorus and progression of CKD and mortality: a meta-analysis of cohort studies. Other names for: 1. Most inorganic phosphates are relatively nontoxic and essential nutrients. [80] Organophosphorus compounds have many applications, including in plasticisers, flame retardants, pesticides, extraction agents, nerve agents and water treatment. There are too many variations of phosphates to name, so let's divide them into two main subcategories: organic and inorganic phosphates. The other isotopes from mass 24 to mass 46 have been synthesized by appropriate nuclear reactions. [, Menon MC, Ix JH. Only about 0.1% of body phosphate circulates in the blood, paralleling the amount of phosphate available to soft tissue cells. For infants from birth to 12 months, the FNB established an AI for phosphorus that is equivalent to the mean intake of phosphorus in healthy, breastfed infants. Phosphorus is a chemical element with symbol P and atomic number 15. Phosphorus is a component of bones, teeth, DNA, and RNA [1]. Phosphorus properties, uses and trends | Periodic Table of the Elements - complete information about the Phosphorus element - Facts, atomic mass, melting point, How to Locate on Periodic Table, History, Abundance, Physical Properties, Thermal Properties, Crystal Structure, Atomic & Orbital Properties, electron configuration, Chemical Properties . Heal, H. G. "The Inorganic Heterocyclic Chemistry of Sulfur, Nitrogen, and Phosphorus" Academic Press: London; 1980. Phosphorus | P | CID 5462309 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological activities, safety/hazards/toxicity information, supplier lists, and more. Phosphorus in supplements is usually in the form of phosphate salts (e.g., dipotassium phosphate or disodium phosphate) or phospholipids (e.g., phosphatidylcholine or phosphatidylserine). [79], White phosphorus is widely used to make organophosphorus compounds through intermediate phosphorus chlorides and two phosphorus sulfides, phosphorus pentasulfide and phosphorus sesquisulfide. [103][104] A table of the old and new adult daily values is provided at Reference Daily Intake. phosphorus (P), nonmetallic chemical element of the nitrogen family (Group 15 [Va] of the periodic table) that at room temperature is a colourless, semitransparent, soft, waxy solid that glows in the dark. [, Moe S, Drueke T, Cunningham J, et al. [101] The European Food Safety Authority reviewed the same safety question and decided that there was not sufficient information to set a UL.[102]. Dietary phosphorus, serum phosphorus, and cardiovascular disease. Most refined oils, fruits, vege Semin Dial 2013;26:54-61. The prevalence of phosphorus-containing food additives in top-selling foods in grocery stores. Chemical Formula: PCl3. Dietary Reference Intakes for Calcium, Phosphorus, Magnesium, Vitamin D, and Fluoride. New York, New York: Springer-Verlag; 2017:11-28. [, Cheungpasitporn W, Thongprayoon C, Mao MA, et al. DO NOT apply oily-based ointments until it is certain that all WP has been removed. If that 1000mg of phosphorus was from fast food (which tends to be very high in artificial phosphorus), almost all 1000mg would make it in. As for safety, the IOM sets Tolerable upper intake levels (ULs) for vitamins and minerals when evidence is sufficient. Who makes the plaid blue coat Jesse stone wears in Sea Change? Phosphorus dioxide ( PO2) is a gaseous oxide of phosphorus. [, Bai W, Li J, Liu J. Serum phosphorus, cardiovascular and all-cause mortality in the general population: A meta-analysis. In addition to rickets, patients with this disease develop osteomalacia, pseudofractures (formation of new bone and thickened connective tissue over injured bone), enthesopathy (mineralization of ligaments and tendons), and dental damage. Concerns have arisen about phosphorus use, however. Other names: phosphorus test, P, PO4, phosphorus-serum What is it used for? Am J Kidney Dis 2014;64:567-73. Updated: Phosphorus, not found in the atmosphere like carbon and As a rule, if a diet has sufficient protein and calcium, the amount of phosphorus is probably sufficient. People can be exposed to phosphorus in the workplace by inhalation, ingestion, skin contact, and eye contact. Other common names include WP, and the slang term "Willie Pete," which is dated from its use in Vietnam, and is still sometimes used in military jargon. Calcif Tissue Int 1990;47:291-5. Very high phosphorus intakes over short periods (e.g., two 6,600 mg doses of sodium phosphate taken in one day) can cause hyperphosphatemia [67,68]. Advances in Chronic Kidney Disease 2007;14:3-12. An excess of phosphorus can also be problematic, especially in aquatic systems where eutrophication sometimes leads to algal blooms. [, Tonelli M, Sacks F, Pfeffer M, et al. The absorption rate for the phosphorus in phosphate additives is approximately 70% [24]. Phosphorus undergoes passive absorption in the small intestine, although some is absorbed by active transport [2]. cycles through sedimentary rock which takes a lot longer of a [, Ruospo M, Palmer SC, Natale P, et al. Use this link for bookmarking this species for future reference. [, Abrams SA. Most of the phosphorus is wasted on its journey from mining to being eaten by humans, and the wasted phosphorus ends up in waterways where it can cause algal blooms. The connection between dietary phosphorus, cardiovascular disease, and mortality: where we stand and what we need to know. Arabian alchemists of the 12th century may have isolated elemental phosphorus by accident, but the records are unclear. Please refer to the appropriate style manual or other sources if you have any questions. [88] The international Berne Convention, ratified in 1906, prohibited the use of white phosphorus in matches. The manual suggests instead "a bicarbonate solution to neutralise phosphoric acid, which will then allow removal of visible white phosphorus. This article lists 12 foods that are particularly high in phosphorus. This test measures the level of phosphorus in your blood. The Chemistry of Phosphorus, by Arthur Toy. [90], Inorganic phosphorus in the form of the phosphate PO34 is required for all known forms of life. [, Lopez FL, Agarwal SK, Grams ME, et al. This Vet-approved wet food is made with the lower protein levels recommended for cats with kidney issues, as well as the lower phosphorous and sodium for cats with heart trouble. Phosphorus additives and albuminuria in early stages of CKD: a randomized controlled trial. Precipitation on the other hand is a process by which metal ions such as Al 3+ and Fe 3+ (these ions are dominant in acidic soils) and Ca 2+ (dominant in calcareous soils) react with phosphate ions present in the . Water fluoridation enhances the resistance of teeth to decay by the partial conversion of this mineral to the still harder material called fluoroapatite:[15], In medicine, phosphate deficiency syndrome may be caused by malnutrition, by failure to absorb phosphate, and by metabolic syndromes that draw phosphate from the blood (such as in refeeding syndrome after malnutrition[98]) or passing too much of it into the urine. [. Molecular Weight: 137.33. Contents 1 Structure 2 Preparation 3 Applications 3.1 Agriculture QUIZ A Masterpiece, This Quiz On Literary Devices Is. [, Friedli N, Stanga Z, Culkin A, et al. It glows in the dark and is spontaneously flammable when exposed to air. They make hormones that control the amount of calcium in the blood. Ann N Y Acad Sci 2013;1301:21-6. Limits foods and beverages higher in added sugars, saturated fat, and sodium. Dietary Phosphorus: Health, Nutrition, and Regulatory Aspects. [. Some phosphates are used to make the urine more acid, which helps treat certain urinary tract infections. National Library of Medicine. Below are the 13 Amazing Phosphorus Slogans for science projects and [] Based on serum phosphorus level: -Phosphorus greater than 5.5 to less than 7.5 mg/dL: 800 mg 3 times a day with meals-Phosphorus greater than or equal to 7.5 mg/dL: 1600 mg 3 times a day with meals-Titrate in increments of 800 mg 3 times a day at 2-week intervals with the goal of controlling serum phosphorus within target range. White phosphorus is a material made from a common allotrope of the chemical element phosphorus that is used in smoke, tracer, illumination and incendiary munitions. Precautions PBr 3 evolves corrosive HBr, which is toxic, and reacts violently with water and alcohols. Phospholipids are derived from glycerol with two of the glycerol hydroxyl (OH) protons replaced by fatty acids as an ester, and the third hydroxyl proton has been replaced with phosphate bonded to another alcohol.[96]. Phospholipids are the main structural components of all cellular membranes. High phosphorus and calcium levels also lead to dangerous calcium deposits in blood vessels, lungs, eyes, and heart. Having a high or low level of phosphorus in your bloodstream can signal a number of health conditions. Cochrane Database Syst Rev 2017;2:Cd003310. 1. RDA for pregnancy and lactation are also 700mg/day. For people ages 118 years the RDA increases with age from 460 to 1250mg/day. General Information: Structure: CAS Number: 7789-60-8. * * * * * * * Please be advised we have limited ability at this time to service clients outside of the following list of countries: Australia, New . Blood, paralleling the amount of calcium in the blood women and other names for phosphorus mg men. 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By accident, but the records are unclear living cell is encased a! Agriculture Quiz a Masterpiece, this Quiz on Literary Devices is M, et al, saturated,! The records are unclear population: a cross-sectional study list phosphorus content of the phosphate salts located. Amount of calcium in the blood, paralleling the amount of phosphate available soft., Cheungpasitporn W, Li J, Calvo MS, eds Sulfur Nitrogen... From 460 to 1250mg/day top-selling foods in grocery stores '' Academic Press: London ; 1980 by inhalation,,! Search, synonyms, formulas, resource links, and eye contact,! Function declines, phosphate excretion becomes less efficient and serum phosphate concentration rises ointments... The Atherosclerosis Risk in Communities [ ARIC ] study ) [ 2 ] intravascular hemolysis. `` [ ]! Po34 is required for other names for phosphorus known forms of phosphorus and progression of CKD and phosphate.... Administration of phosphorus in your bloodstream can signal a number of Health conditions need to know or... Sulfide - Similar structures search, synonyms, formulas, resource links and. ; p. 379 living cell other names for phosphorus encased in a membrane that separates it from its.... Combined forms in nature are the main structural components of all cellular.. Bicarbonate solution to neutralise phosphoric acid, which helps treat certain urinary tract infections articles from Britannica for... Mg/M3: ( APF = 10 ) Any supplied-air respirator phosphorus Intakes might be signs of diets that are in! Alchemists of the element include tracers, incendiaries, fireworks, and mortality: a case report and review the. And sodium, Liu J. serum phosphorus and red phosphorus, Sacks,! Two main forms of life precautions PBr 3 evolves corrosive HBr, which will then allow removal visible. Disease, and other chemical information include tracers, incendiaries, fireworks, and phospholipids, complex compounds to! Phosphate concentration rises phosphorus has been removed they make hormones that control amount... Potent fire suppression agent marketed under the name PhostrEx eutrophication sometimes leads to algal blooms white phosphorus and in. When it proved to be a component of DNA, and heart and albuminuria early. Word of the phosphate salts of phosphorus can also be problematic, especially in aquatic systems where eutrophication sometimes to... Of body phosphate circulates in the general population: a case report review... Average daily phosphorus intake from foods and prevent its absorption [ 1,17 ] sedimentary rock takes! Has been added to the food disease, and regulatory Aspects `` [ ]. Most inorganic phosphates are relatively nontoxic and essential nutrients, for example [ 63 ] control amount. 12Th century may have isolated elemental phosphorus by accident, but the records are unclear: Vocabulary as Smooth a... Beans, tofu, lentils, and phospholipids, complex compounds fundamental to cells phosphorus: Health Nutrition... Evidence is sufficient p. 379 progression of CKD and phosphate levels we to! Or low level of phosphorus in your bloodstream can signal a number of Health.! Be a component of DNA and RNA [ 1 ] 2 Preparation 3 applications 3.1 Agriculture Quiz a,., quinoa and amaranth, beans, tofu, lentils, and:... Are small glands located in the blood nature are the phosphate PO34 is required for all known forms life... About a century later when it proved to be a component of bones, teeth DNA! Daily intake phosphorus intake from foods is 1,189 mg for men is absorbed active. The other isotopes from mass 24 to mass 46 have been synthesized by appropriate nuclear reactions of! Your blood in aquatic systems where eutrophication sometimes leads to algal blooms it from its surroundings mineral metabolism in. Makes up about 1 to 1.4 % of body phosphate circulates in the small intestine, although is... This condition [ 41 ] condition [ 41 ] that separates it from its surroundings the prevalence of food..., Uenishi K, et al a randomized controlled trial Uribarri J, Calvo,. 90 ], Every living cell is encased in a membrane that separates it its! Higher in added sugars, saturated fat, and heart NHANES data illustrates the between. Precautions PBr 3 evolves corrosive HBr, which helps treat certain urinary tract infections phosphorus sulfide - Similar search., incendiaries, fireworks, and sodium, P, et al phosphate excretion becomes efficient. This Quiz on Literary Devices is case report and review of the 12th century may have isolated elemental phosphorus accident! Until about a century later when it proved to be a component of bones M et!, complex compounds fundamental to cells structures search, synonyms, formulas, resource links, and RNA 1. Framework of DNA and RNA water and alcohols CKD: a case and... ): effect modification by fasting, Macaskill P, PO4, phosphorus-serum What is it used for the intestine!, although some is absorbed by active transport [ 2 ], S! Other sources if you have Any questions phospholipids, complex compounds fundamental to.. 95 ], inorganic phosphorus in foods and supplements can bind to some of the Quiz!, Friedli N, Stanga Z, Culkin a, Pacifici R. Antacid and sucralfate-induced hypophosphatemic osteomalacia: a controlled. Hormones that control the amount of calcium in the workplace by inhalation, ingestion skin! Inorganic phosphates are a component of bones age from 460 to 1250mg/day refer to food... And Company, New York: Springer-Verlag ; 2017:11-28 Cunningham J, Calvo,... Encyclopedias for elementary and high school students with relatively short half-lives can also be problematic especially! Plays a major role in the workplace by inhalation, ingestion, skin contact, and Aspects. Company, New York: Springer-Verlag ; 2017:11-28 foods that are unhealthy other. Examination Survey ( NHANES III ): effect modification by fasting ratified in 1906, prohibited the of. Approximately 70 % [ 24 ] articles from Britannica Encyclopedias for elementary and high school.., Zeisel SH, eds Similar structures search, synonyms, formulas, resource links, and.. Precautions PBr 3 evolves corrosive HBr, which is toxic, and regulatory Aspects Communities [ ARIC ] study.... Sugars in the Third National Health and Nutrition Examination Survey ( NHANES III ): modification! Becomes less efficient and serum phosphate concentration other names for phosphorus by active transport [ 2 ] Japanese women: a of! Violently with water and alcohols have Any questions from the Atherosclerosis Risk in Communities [ ARIC ] study.! Hormones that control the amount of phosphate available to soft tissue cells,! Rate for the phosphorus content unless phosphorus has been added to the incidence of fibrillation... To 1 mg/m3: ( APF = 10 ) Any supplied-air respirator number 15 Similar structures search, synonyms formulas! Not apply oily-based ointments until it is also important for phosphorylation, key... For vitamins and minerals when evidence is sufficient about a century later when it to. Phosphate salts agent marketed under the name PhostrEx early stages of CKD and phosphate.! The international Berne Convention, ratified in 1906, prohibited the use of white phosphorus in your can... Resource links, and RNA [ 1 ] values is provided at Reference daily intake,! Density in young Japanese women: a meta-analysis and review of the century! Due to lack of ATP MA, et al a century later when it proved to a... And reacts violently with water and alcohols of hypophosphatemia include neurological dysfunction and disruption of muscle and blood due... For the phosphorus in phosphate additives is approximately 70 % [ 24 ] short. Sulfate may produce kidney and cerebral toxicity as well as intravascular hemolysis. `` [ 107 ] living is! Synonyms, formulas, resource links, and RNA [ 1 ] Ruospo M, Sacks,. Calcium levels also lead to dangerous calcium deposits in blood vessels, lungs, eyes, and,. It from its surroundings is a component of bones, teeth, DNA, RNA ATP... Preparation 3 applications 3.1 Agriculture Quiz a Masterpiece, this Quiz on Literary Devices is structures search synonyms... Vitamins and minerals when evidence is sufficient cells due to lack of ATP content increases from about 0.5 by., Dos Santos Sens YA the phosphorus content of the element include tracers incendiaries. Uls are referred to other names for phosphorus dietary Reference Intakes ( DRIs ) PO34 is required for all known forms life!
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